More on Membranes in Matrix Theory

We study noncompact and static membrane solutions in Matrix theory. Demanding axial symmetry on a membrane embedded in three spatial dimensions, we obtain a wormhole solution whose shape is the same with the catenoidal solution of Born-Infeld theory. We also discuss another interesting class of solutions, membranes embedded holomorphically in four spatial dimensions, which are 1/4 BPS.Comment: 7 pages, LaTeX; expanded to treat matrix membrane solutions with electric flux, equivalently fundamental strings; to appear in Phys. Rev.

Spatiotemporal chaos and quasipatterns in coupled reaction–diffusion systems

In coupled reaction–diffusion systems, modes with two different length scales can interact to produce a wide variety of spatiotemporal patterns. Three-wave interactions between these modes can explain the occurrence of spatially complex steady patterns and time-varying states including spatiotemporal chaos. The interactions can take the form of two short waves with different orientations interacting with one long wave, or vice verse. We investigate the role of such three-wave interactions in a coupled Brusselator system. As well as finding simple steady patterns when the waves reinforce each other, we can also find spatially complex but steady patterns, including quasipatterns. When the waves compete with each other, time varying states such as spatiotemporal chaos are also possible. The signs of the quadratic coefficients in three-wave interaction equations distinguish between these two cases. By manipulating parameters of the chemical model, the formation of these various states can be encouraged, as we confirm through extensive numerical simulation. Our arguments allow us to predict when spatiotemporal chaos might be found: standard nonlinear methods fail in this case. The arguments are quite general and apply to a wide class of pattern-forming systems, including the Faraday wave experiment

Optimisation of methods for bacterial skin microbiome investigation: primer selection and comparison of the 454 versus MiSeq platform

BACKGROUND: The composition of the skin microbiome is predicted to play a role in the development of conditions such as atopic eczema and psoriasis. 16S rRNA gene sequencing allows the investigation of bacterial microbiota. A significant challenge in this field is development of cost effective high throughput methodologies for the robust interrogation of the skin microbiota, where biomass is low. Here we describe validation of methodologies for 16S rRNA (ribosomal ribonucleic acid) gene sequencing from the skin microbiome, using the Illumina MiSeq platform, the selection of primer to amplify regions for sequencing and we compare results with the current standard protocols.. METHODS: DNA was obtained from two low density mock communities of 11 diverse bacterial strains (with and without human DNA supplementation) and from swabs taken from the skin of healthy volunteers. This was amplified using primer pairs covering hypervariable regions of the 16S rRNA gene: primers 63F and 519R (V1-V3); and 347F and 803R (V3-V4). The resultant libraries were indexed for the MiSeq and Roche454 and sequenced. Both data sets were denoised, cleaned of chimeras and analysed using QIIME. RESULTS: There was no significant difference in the diversity indices at the phylum and the genus level observed between the platforms. The capture of diversity using the low density mock community samples demonstrated that the primer pair spanning the V3-V4 hypervariable region had better capture when compared to the primer pair for the V1-V3 region and was robust to spiking with human DNA. The pilot data generated using the V3-V4 region from the skin of healthy volunteers was consistent with these results, even at the genus level (Staphylococcus, Propionibacterium, Corynebacterium, Paracoccus, Micrococcus, Enhydrobacter and Deinococcus identified at similar abundances on both platforms). CONCLUSIONS: The results suggest that the bacterial community diversity captured using the V3-V4 16S rRNA hypervariable region from sequencing using the MiSeq platform is comparable to the Roche454 GS Junior platform. These findings provide evidence that the optimised method can be used in human clinical samples of low bacterial biomass such as the investigation of the skin microbiota. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12866-017-0927-4) contains supplementary material, which is available to authorized users

Medication Adherence, Burden and Health-Related Quality of Life in Adults with Predialysis Chronic Kidney Disease: A Prospective Cohort Study

This study examines the associations between medication adherence and burden, and health-related quality of life (HRQOL) in predialysis chronic kidney disease (CKD). A prospective study targeting adults with advanced CKD (estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2 ) and not receiving renal replacement therapy was conducted in Tasmania, Australia. The actual medication burden was assessed using the 65-item Medication Regimen Complexity Index, whereas perceived burden was self-reported using a brief validated questionnaire. Medication adherence was assessed using a four-item Morisky-Green-Levine Scale (MGLS) and the Tool for Adherence Behaviour Screening (TABS). The Kidney Disease and Quality of Life Short-Form was used to assess HRQOL. Of 464 eligible adults, 101 participated in the baseline interview and 63 completed a follow-up interview at around 14 months. Participants were predominantly men (67%), with a mean age of 72 (SD 11) years and eGFR of 21 (SD 6) mL/min/1.73 m2 . Overall, 43% and 60% of participants reported medication nonadherence based on MGLS and TABS, respectively. Higher perceived medication burden and desire for decision-making were associated with nonadherent behaviour. Poorer HRQOL was associated with higher regimen complexity, whereas nonadherence was associated with a decline in physical HRQOL over time. Medication nonadherence, driven by perceived medication burden, was prevalent in this cohort, and was associated with a decline in physical HRQOL over time

Noncommutative D-Brane in Non-Constant NS-NS B Field Background

We show that when the field strength H of the NS-NS B field does not vanish, the coordinates X and momenta P of an open string endpoints satisfy a set of mixed commutation relations among themselves. Identifying X and P with the coordinates and derivatives of the D-brane world volume, we find a new type of noncommutative spaces which is very different from those associated with a constant B field background.Comment: 11 pages, Latex, minor modification

Non-Abelian BIonic Brane Intersections

We study "fuzzy funnel" solutions to the non-Abelian equations of motion of the D-string. Our funnel describes n^6/360 coincident D-strings ending on n^3/6 D7-branes, in terms of a fuzzy six-sphere which expands along the string. We also provide a dual description of this configuration in terms of the world volume theory of the D7-branes. Our work makes use of an interesting non-linear higher dimensional generalization of the instanton equations.Comment: 17 pages uses harvmac; v2: small typos corrected, refs adde

Alopecia areata is characterized by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease‐associated psychological morbidity

Background: Alopecia areata (AA) is a common autoimmune disease, causing patchy hair loss that can progress to involve the entire scalp (totalis) or body (universalis). CD8+NKG2D+ T cells dominate hair follicle pathogenesis, but the specific mechanisms driving hair loss are not fully understood. Objectives To provide a detailed insight into the systemic cytokine signature associated with AA, and assess the association between cytokines and depression. Methods: Multiplex analysis of plasma cytokines from AA patients, psoriatic arthritis (PsA) patients and healthy controls. We also assessed incidence of depression and anxiety using the Hospital Anxiety and Depression Scale. Results: Our analysis identified a systemic inflammatory signature associated with AA, characterised by elevated levels of IL-17A, IL-17F, IL-21 and IL-23 indicative of a type 17 immune response. Circulating levels of the type 2 cytokines IL-33, IL-31 and IL-17E/25 are also significantly increased in AA. In comparison to PsA, AA was associated with higher levels of IL-17F, IL-17E and IL-23. We hypothesised that circulating inflammatory cytokines may contribute to wider comorbidities associated with AA. We assessed psychiatric comorbidity in AA using the Hospital Anxiety and Depression Scale and found that 18% and 51% of people with AA experienced symptoms of depression and anxiety, respectively. Using linear regression modelling, we identified that levels of IL-22 and IL-17E are positively and significantly associated with depression. Conclusion: Our data highlight changes in both type 17 and 2 cytokines, suggesting that complex systemic cytokine profiles may contribute both to the pathogenesis of AA and to the associated depression

Scalar Field Theory on Fuzzy S^4

Scalar fields are studied on fuzzy $S^4$ and a solution is found for the elimination of the unwanted degrees of freedom that occur in the model. The resulting theory can be interpreted as a Kaluza-Klein reduction of CP^3 to S^4 in the fuzzy context.Comment: 16 pages, LaTe

Effect of pharmacist‐led medication review on medication appropriateness in older adults with chronic kidney disease

This study evaluated the effect of pharmacist‐led review on medication appropriateness in 204 older patients with chronic kidney disease (CKD) admitted to an Australian hospital. Medication appropriateness was evaluated using the Medication Appropriateness Index (MAI) prior to medication review, after review (assuming all recommendations were accepted by physicians) and after outcome (acceptance/non‐acceptance) of recommendations. Overall, 95 patients (46%) received a medication review by pharmacists. The median (interquartile range) MAI score decreased significantly from a baseline of 7 (3–12) to 5 (2–10) after medication review (p < 0.001) and to 6 (2–10) after the outcome of recommendations (p < 0.01). The MAI score also decreased in patients with no medication review by a pharmacist from 6 (3–11) at admission to 5 (2–9) at discharge (p < 0.001). MAI scores declined markedly in people with all pharmacist‐conducted medication review recommendations accepted (from 7 to 3; p < 0.05). Reassuringly, hospitalisation alone improved medication appropriateness. However, pharmacist‐led medication review can further optimise medication appropriateness in older CKD patients, particularly when the recommendations are implemented